Cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidiorcol (CBDC) Cannabidiol-C4 (CBDC), cannabidiol dimethyl ether (CBDD), cannabidiol monomethyl ether (CBDM), cannabidivarin (CBDV), cannabidivarinic acid (CBDVA) This list of cannabinoids contains the best known and most studied cannabinoids Deposits of these compounds. Tetrahydrocannabinol (THC) is the best-known cannabinoid and is the chemical substance responsible for much of the psychoactive (psychotropic) and euphoric effects of cannabis, in addition to being used to treat serious illnesses such as PTSD and cancer. Cannabidiol (CBD), a generally non-psychoactive compound that has been shown to provide a wide range of medical benefits, such as pain relief, anxiety relief and depression relief, is another notable cannabinoid. Most people are familiar with tetrahydrocannabinol (THC) and cannabidiol (CBD).
While THC and CBD are definitely important cannabinoids, there are many more worth exploring. While the endocannabinoid system can use THC and CBD, it can also use MANY more cannabinoids. At the time of writing this article, we know about 113 cannabinoids in the marijuana plant. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the best known.
Even when you focus only on these two, you see the significant differences between them. The main reason we know more about them than others is because they are the most abundant cannabinoids in marijuana. While we won't talk about 113 cannabinoids, we'll focus on 10 of the most important ones, including the two most important. Read to learn more about these compounds and their potential effects on your health.
Researchers discovered the ECS in the late 1980s. It is found in all central and peripheral nervous systems and helps regulate the body in an attempt to create balance or homeostasis. Cannabinoids in marijuana can bind to CB1 receptor sites (mainly in the brain) and to CB2 receptor sites (mainly in the body). Marijuana isn't the only plant that contains phytocannabinoids.
Species such as Acmella oleracea, Radula marginata and Echinacea Angustifolia contain these compounds. The lipophilic alkamides (alkylamides) of the species Echinacea are probably the best-known cannabinoids that DO NOT come from the herb. Researchers have discovered 25 alkylamines to date, some of which have an affinity for the CB 2 receptor. You can “consume” cannabinoids by smoking, vaping, injecting yourself intravenously, through suppositories, sublingual absorption, transdermal patches, topical medications and through oral ingestion.
When cannabinoids enter the body, the liver metabolizes them. Intravenous injection provides the highest bioavailability, followed by vaping. With methods such as oral ingestion and sublingual absorption, the body absorbs as little as 10 to 20%. For example, the hemp plant is cultivated for a higher CBD content, while marijuana growers are continuously trying to create a higher level of THC.
While the cannabis plant rarely contains more than 1% of cannabinoids other than THC or CBD, we will soon reach a stage where breeders will grow plants with high percentages of lesser-known cannabinoids. This is especially the case if research shows that other cannabinoids have significant medical potential. Now, let's take a look at 10 of the most important cannabinoids in marijuana. First, we'll provide a brief description of each.
Unlike THC, CBD doesn't directly activate our brain's CB1 receptors, meaning users don't feel the same intoxicating effects. Instead, CBD appears to increase the level of endocannabinoids (2-AG and anandamide) in the body. There is evidence that CBD interacts with brain cells, including opioid receptors, which regulate pain, and dopamine receptors, which control behavior. THCV binds to the CB1 and CB2 receptors of the ECS.
The binding process depends on the dose. The level of research on this cannabinoid has increased exponentially in recent times, as its apparent health benefits become known. CBG is arguably one of the two most essential cannabinoids of all, but few people have heard of it. It is the chemical parent of THC and CBD.
In other words, both cannabinoids start as CBG and wouldn't exist without it. Although marijuana strains contain less than 1% of this cannabinoid, it is essential to produce cannabinoids that provide medicinal benefits. Researchers discovered CBGA, the acid form of CBG, in the 1970s. They soon realized that CBGA was the forerunner of the best-known cannabinoids.
CBG comes from a process called biosynthesis, which is based on chemical reactions that produce other chemical components. Based on data from the 1970s, you'll find massive levels of CBC in strains native to India. It is more common than CBD in a surprising number of strains. CBC also works well when combined with other cannabinoids in what is called the “entourage effect”.
However, some sources say that Robert Sidney Conn, a British chemist, discovered cannabinol in the 1930s. It is a mildly intoxicating cannabinoid related to a reduction in pain. A study by Zygmunt et al. For a long time, researchers believed that CBDA, and therefore raw hemp, had no medical benefit until it was converted to CBD.
However, CBDA has an impact on the body. Like CBD, it does not interact directly with ECS receptors. Instead, it activates serotonin 5-HT1A receptors. As you may already know, serotonin is a type of neurotransmitter found in the brain.
Regulates anxiety, sleep, nausea, anxiety and mood. It is a non-intoxicating cannabinoid and appears to act as a low-affinity CB1 receptor antagonist. Researchers continue to study whether CBGA affects CB2 receptors. Most medical marijuana strains contain CBGA, which doesn't quickly convert to other cannabinoids.
Ultimately, we've barely scratched the surface when it came to determining the benefits of the cannabinoids in marijuana. There are approximately 113 of them, and less than 10% have been investigated to any degree. Then there's the small question of the hundreds of other compounds that we have yet to delve into. Cannabinoids can be found in virtually every part of the cannabis plant; however, flowers contain the most.
Cannabis produces a variety of compounds known as plant cannabinoids, many of which have not been detected in any other plant. When cannabinoid acids are exposed to thermal energy, they lose the “A” part and become neutral plant cannabinoids, rather than acids (Figure. Tetrahydrocannabinol rapidly binds to CB1 receptors in the brain, producing the intoxicating effects we expected from cannabinoids with a high THC content. CBG, or cannabigerol, is a non-intoxicating cannabinoid marketed to relieve anxiety, pain, infections, inflammation, nausea, and even for the treatment of cancer.
Each cannabinoid profile contains the name, chemical structure, how it is used and a list of potential therapeutic benefits. While you've probably heard of THC and CBD, you may not be aware of the dozens of other cannabinoids that work together to affect the body in a variety of ways. The cannabinoid CBN, or cannabinol, is present in small amounts in the cannabis plant, but is mainly a by-product of the degradation of THC. CBG is another non-psychoactive cannabinoid, but it's not as well known because it's found in small amounts in most strains.
You've probably heard of THC and CBD, but other well-known classifications of cannabinoids include CBN (Cannabinol), CBC (Cannabichromene) and CBG (cannabigerol). That said, several cannabinoids are starting to appear in wellness supplements and even in certain medications. . .