Although THC is the best known, a deeper understanding of the chemical structures of non-psychoactive cannabinoids such as CBD, CBG, CBN and CBC and their effects allows us to understand the emerging product landscape. This list of cannabinoids contains the most well-known and studied compounds. Tetrahydrocannabinol (THC) is the best-known cannabinoid and is the chemical responsible for much of the psychoactive (psychotropic) and euphoric effects of cannabis, in addition to being used to treat serious illnesses such as PTSD and cancer. Cannabidiol (CBD), a generally non-psychoactive compound that has been shown to provide a wide range of medical benefits, such as pain relief, anxiety relief and depression relief, is another notable cannabinoid.
Meta-regression and stratified analysis showed no evidence of a difference in the association of cannabinoids with the incidence of “any EA” depending on the type of cannabinoid, study design, indication, comparator, or duration of follow-up.15,16,18,22-26,28-31,33-31,33-38,41,42,44-47,51,57,58,60,664-2,69,76,69,769,72-85, 87.88, 123 - 127, 129 - 131, 159, 160, 162; additional analyses were performed for all studies combined. Despite the increasing harmful problems resulting from the use of cannabis, studies have shown that this drug and some SCs can have a number of therapeutic effects, depending on the specific dosage. Most studies suggested that cannabinoids were associated with improvements in symptoms, but these associations did not reach statistical significance in all studies. Most of the studies were 2-group trials with a placebo control group; however, some studies included active comparisons and several groups in which more than one form of cannabinoid, different doses of cannabinoids, or active and placebo comparison groups were compared.
Two studies (5 reports; 54 participants) evaluated cannabinoids (nabilone) specifically for the treatment of sleep problems. More studies evaluating cannabis itself are also needed because there is very little evidence on the effects and AEs of cannabis. It was formerly thought that cannabinoids were only found in the cannabis plant, but studies have found that they can also be found in carrots, broccoli, ginseng, echinacea and black pepper. The studies evaluated several forms of cannabis administered by various routes (oral capsules, smoked, vaporized, oromucosal aerosol, by intramuscular injection) and the active comparators differed from trial to trial.
It is important to identify many cannabinoids in cannabis, as medical studies show that they could improve diseases such as arthritis, digestive difficulties, anxiety and discomfort. Cannabinoids are studied in a variety of ways, from a physiological operating medium to biochemical and chemical. The searches identified 23,754 visits (records), of which 505 were considered potentially relevant, based on the selection of the title and abstract, and were obtained as full-text studies. Three studies suggested that there was no difference between cannabinoids (dronabinol and nabiximoles) and placebo in depression outcomes.
Studies generally suggested improvements in pain measurements associated with cannabinoids, but these did not reach statistical significance in most individual studies.
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