The main difference between the two cannabinoids is that THC has strong psychoactive effects, meaning that it causes a person to “get high”, while CBD is believed to have an antipsychoactive effect that controls or moderates the “high” caused by THC. Other cannabinoids, such as CBD (cannabidiol), have no pleasurable psychoactive effects, but are attracting enormous medical interest from pharmaceutical companies eager to learn more about their medicinal properties. However, this is another little-studied example of a plant cannabinoid, and more work needs to be done before we can rely on its precise effects. CB1 receptors: effects of endocannabinoids and the release of D-9-THC from anandamide (AEA) and 2-arachidonoylglycerol (2-AG) to inhibit glutamate (Glu), gamma-aminobutyric acid (GABA), acetylcholine (Ach), dopamine, noradrenaline (NA) and serotonin (5-HT).
What many people don't know is that the plant contains hundreds of cannabinoids, all with incredibly specific effects and benefits. Questions such as “which cannabinoids amplify the effects of others” remain almost impossible to answer. This deficiency remains controversial among medical experts, but more science continues to be developed to support the idea and explain why cannabis appears to be so effective for certain refractory disorders. Aged cannabinoids may have very different properties and effects than their raw or hot predecessors.
Still, having a general idea of the effects of primary cannabinoids can go a long way in determining which products are right for you. In addition to the schizotypic personality, factors of vulnerability to the psychogenic effects of cannabis need to be replicated. This cannabinoid has much in common with its chemical cousin, THC, but it has a slightly different chemical structure and effect profile. Medical cannabis has been found to have a wide range of health benefits for people suffering from diseases, such as eliminating malignant tumors, anxiety and depression, relieving arthritis pain through anti-inflammatory effects, and reducing the number of seizures suffered by epileptic children.
Another commonly known cannabinoid is cannabidiol (CBD), which is praised for its medicinal benefits without its intoxicating effects. The authors discovered that the genetic variation of the serine-threonine protein kinase (AKT) may mediate the short- and long-term effects on the expression of psychosis associated with cannabis use.