The adolescent brain is not yet fully mature, and neurodevelopment continues at least until the early or mid-20s. During adolescence, the brain is particularly sensitive to drug exposure, and marijuana use affects the way connections are formed within the brain. 3) Other effects on the developing brain include interference with neurotransmitters and the abnormal shape and volume of the brain. 6.Smoking marijuana in adolescence can have lasting effects.
The area of the brain involved in decision-making developed differently in adolescents who used cannabis than in peers who stayed away from To understand the effects of cannabis on adolescent brain function and development, a clinical psychologist performs brain scans on adolescents adolescents who use the drug and those who do not use it. Effects of short-term treatment with cannabidiol on the response to social stress in subjects at high clinical risk of developing psychosis. Chronic cannabinoid treatment for puberty, but not for adults, impairs sensorimotor activation, recognition memory and performance in a progressive proportion task in adult rats. Brief presynaptic bursts cause specific retrograde synapse-mediated retrograde inhibition by endogenous cannabinoids.
It is possible that the alteration of cognitive function and the alteration of the neural substrates that underlie these cognitive processes, as summarized above, could be the cause of worse educational outcomes and an increase in the school dropout rate (68, 69, 145 to 15) among early-onset cannabis users. Adolescent cannabis users show altered functional connectivity within known functional circuits, which may be the basis for inefficient recruitment of brain regions, since a large increase in functional activation has been observed Alterations in GABAergic transmission of prefrontal cortex in the complex psychotic phenotype induced by exposure to delta-9-tetrahydrocannabinol in adolescents in rats. However, compared to controls for adolescents who did not use them, no alteration in activation was observed in adolescent cannabis users during reward (8) or inhibition processing. When a person uses marijuana, the main psychoactive chemical called tetrahydrocannabinol (THC) goes from the lungs (when smoking) or from the digestive tract (with food) to the bloodstream.
In light of the cross-sectional design of most studies, much of the currently available human evidence is unable to unravel the nature of the relationship between adolescent cannabis use and neurocognitive disorders, i.e., there are currently no systematic studies with adequate potency. with well-defined groups of early-onset and late-onset cannabis users comparing potential confounding factors, such as levels of exposure to cannabis, which could help begin to address the question of whether cannabis use during adolescence is associated with greater structural and functional alterations Of the brain that I later used initially. This is particularly true of substances that attack the endocannabinoid system, which, together with its other functions, plays a vital role in adolescent neuronal maturation (2). While performing inhibitory processing tasks, early-onset cannabis users had impaired functioning, as they activated different regions of the anterior cinulate cortex (ACC) compared to controls, while late-onset users showed activation patterns similar to those of a non-consumer control group (93, 9.Interestingly, an earlier age at the onset of cannabis use has also been associated with an increase in white matter volume (8), orbitofrontal connectivity (120) and the cortical thickness of the superior frontal gyrus (80).
A subsequent study of adult cannabis users with a narrow age range at the onset of cannabis use during adolescence found evidence of inefficient medial temporal and midbrain function, which explains slower verbal learning (130). .
Leave a Comment